Cigarette smoking and personality: interrogating causality using Mendelian randomisation.

ABSTRACT:

Background

Despite the well-documented association between smoking and personality traits such as neuroticism and extraversion, little is known about the potential causal nature of these findings. If it were possible to unpick the association between personality and smoking, it may be possible to develop tailored smoking interventions that could lead to both improved uptake and efficacy.

Methods

Recent genome-wide association studies (GWAS) have identified variants robustly associated with both smoking phenotypes and personality traits. Here we use publicly available GWAS summary statistics in addition to individual-level data from UK Biobank to investigate the link between smoking and personality. We first estimate genetic overlap between traits using LD score regression an

SUBMITTER: Sallis HM 

PROVIDER: S-EPMC6747344 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature