Dynamic mRNA Expression Analysis of the Secondary Palatal Morphogenesis in Miniature Pigs.

ABSTRACT: Normal mammalian palatogenesis is a complex process that requires the occurrence of a tightly regulated series of specific and sequentially regulated cellular events. Cleft lip/palate (CLP), the most frequent craniofacial malformation birth defects, may occur if any of these events undergo abnormal interference. Such defects not only affect the patients, but also pose a financial risk for the families. In our recent study, the miniature pig was shown to be a valuable alternative large animal model for exploring human palate development by histology. However, few reports exist in the literature to document gene expression and function during swine palatogenesis. To better understand the genetic regulation of palate development, an mRNA expression profiling analysis was performed on miniatur

SUBMITTER: Liu J 

PROVIDER: S-EPMC6747431 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature