Methotrimeprazine versus haloperidol in palliative care patients with cancer-related nausea: a randomised, double-blind controlled trial.

ABSTRACT:

Objectives

Methotrimeprazine is commonly used for the management of nausea but never tested formally against other drugs used in this setting. The aim was to demonstrate superior antiemetic efficacy.

Design

Double-blind, randomised, controlled trial of methotrimeprazine versus haloperidol.

Setting

11 palliative care sites in Australia.

Participants

Participants were >18 years, had cancer, an average nausea score of ≥3/10 and able to tolerate oral medications. Ineligible patients had acute nausea related to treatment, nausea for which a specific antiemetic was indicated, were about to undergo a procedure or had received either of the study drugs or a change in glucocorticoid dose within the previous 48 hours.

Interventions

Based on previous studies, halop

SUBMITTER: Hardy JR 

PROVIDER: S-EPMC6747674 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature