Controlling Visually Guided Behavior by Holographic Recalling of Cortical Ensembles.

ABSTRACT: Neurons in cortical circuits are often coactivated as ensembles, yet it is unclear whether ensembles play a functional role in behavior. Some ensemble neurons have pattern completion properties, triggering the entire ensemble when activated. Using two-photon holographic optogenetics in mouse primary visual cortex, we tested whether recalling ensembles by activating pattern completion neurons alters behavioral performance in a visual task. Disruption of behaviorally relevant ensembles by activation of non-selective neurons decreased performance, whereas activation of only two pattern completion neurons from behaviorally relevant ensembles improved performance, by reliably recalling the whole ensemble. Also, inappropriate behavioral choices were evoked by the mistaken activation of behaviora

SUBMITTER: Carrillo-Reid L 

PROVIDER: S-EPMC6747687 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature