A near infrared light-triggerable modular formulation for the delivery of small biomolecules.

ABSTRACT:

Background

Externally triggered drug delivery systems hold considerable promise for improving the treatment of many diseases, in particular, diseases where the spatial-temporal release of the drug is critical to maximize their biological effect whilst minimizing undesirable, off-target, side effects.

Results

Herein, we developed a light-triggerable formulation that takes advantage of host-guest chemistry to complex drugs functionalized with a guest molecule and release it after exposure to near infrared (NIR) light due to the disruption of the non-covalent host-guest interactions. The system is composed by a gold nanorod (AuNR), which generates plasmonic heat after exposure to NIR, a thin layer of hyaluronic acid immobilized to the AuNR upon functionalization with a macrocyc

SUBMITTER: Francisco V 

PROVIDER: S-EPMC6747754 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature