Design Variation of a Dual-Antigen Liposomal Vaccine Carrier System.

ABSTRACT: The enclosed work focuses on the construction variables associated with a dual-antigen liposomal carrier, delivering encapsulated polysaccharides and surface-localized proteins, which served as a vaccine delivery device effective against pneumococcal disease. Here, the goal was to better characterize and compare the carrier across a range of formulation steps and assessment metrics. Specifically, the vaccine carrier was subjected to new methods of liposomal formation, including alterations to the base components used for subsequent macromolecule encapsulation and surface attachment, with characterization spanning polysaccharide encapsulation, liposomal size and charge, and surface protein localization. Results demonstrate variations across the liposomal constructs comprised two means of su

SUBMITTER: Nayerhoda R 

PROVIDER: S-EPMC6747791 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature