PDMS-PMOXA-Nanoparticles Featuring a Cathepsin B-Triggered Release Mechanism.

ABSTRACT:

Background

It was our intention to develop cathepsin B-sensitive nanoparticles for tumor-site-directed release. These nanoparticles should be able to release their payload as close to the tumor site with a decrease of off-target effects in mind. Cathepsin B, a lysosomal cysteine protease, is associated with premalignant lesions and invasive stages of cancer. Previous studies have shown cathepsin B in lysosomes and in the extracellular matrix. Therefore, this enzyme qualifies as a trigger for such an approach.

Methods

Poly(dimethylsiloxane)-b-poly(methyloxazoline) (PDMS-PMOXA) nanoparticles loaded with paclitaxel were formed by a thin-film technique and standard coupling reactions were used for surface modifications. Despite the controlled release mechanism, the physical prop

SUBMITTER: Ehrsam D 

PROVIDER: S-EPMC6747961 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature