HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin.

ABSTRACT: HIV-associated neurocognitive disorders (HAND) is a syndrome defined by neurocognitive deficits that are driven by viral neurotoxins, cytokines, free radicals, and proteases expressed in the brain. This neurological disease has also been linked to activation of Protease-Activated Receptors 1 and 2 (PAR1,2). These receptors are highly expressed in the central nervous system and are upregulated in HAND. Secretory basic-amino-acid-specific Proprotein Convertases (PCs), which cleave precursor proteins at basic residues, are also induced in HAND. They are vital for many biological processes including HIV-1 entry into cells. The cytoprotective role of Furin, PC5, and PACE4 has been linked to the presence of a potential PC-cleavage site R₄₁XXXXR₄₆↓ in PAR1. Furthermore, Furi

SUBMITTER: Sachan V 

PROVIDER: S-EPMC6748122 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature