Abnormal Cerebral Perfusion Profile in Older Adults with HIV-Associated Neurocognitive Disorder: Discriminative Power of Arterial Spin-Labeling.

ABSTRACT:

Background and purpose

The aging HIV-infected (HIV⁺) population has increased vascular comorbidities, including stroke, and increased cognitive deficits compared with the general population. Arterial spin-labeling is a technique to measure cerebral blood flow and is more sensitive than regional volume loss in assessing neurodegenerative diseases and cognitive aging. Previous studies have found global cerebral perfusion abnormalities in the HIV⁺ participants. In this study, we evaluated the specific regional pattern of CBF abnormalities in older HIV⁺ participants using quantitative whole-brain arterial spin-labeling.

Materials and methods

CBF data from the UCSF HIV Over 60 Cohort and the Alzheimer Disease Neuroimaging Initiative were retrospec

SUBMITTER: Narvid J 

PROVIDER: S-EPMC6748330 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature