Neighborhood Disadvantage and Biological Aging: Using Marginal Structural Models to Assess the Link Between Neighborhood Census Variables and Epigenetic Aging.

ABSTRACT:

Objectives

Past research has reported an association between neighborhood disadvantage and healthy aging, but most of these studies utilize self-report measures of health or physical functioning and do not properly account for neighborhood selection effects, creating concerns regarding inflated associations. To overcome these limitations and provide a more stringent estimate of effects, the current study investigated the effect of neighborhood disadvantage on aging using newly developed epigenetic methods to assess rate of biological aging and marginal structural modeling (MSM) to account for potential confounds due to neighborhood selection.

Methods

We tested the hypothesis that neighborhood disadvantage accelerates aging using U.S. census data and five waves of interview d

SUBMITTER: Lei MK 

PROVIDER: S-EPMC6748734 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature