Differential network enrichment analysis reveals novel lipid pathways in chronic kidney disease.

ABSTRACT:

Motivation

Functional enrichment testing methods can reduce data comprising hundreds of altered biomolecules to smaller sets of altered biological 'concepts' that help generate testable hypotheses. This study leveraged differential network enrichment analysis methodology to identify and validate lipid subnetworks that potentially differentiate chronic kidney disease (CKD) by severity or progression.

Results

We built a partial correlation interaction network, identified highly connected network components, applied network-based gene-set analysis to identify differentially enriched subnetworks, and compared the subnetworks in patients with early-stage versus late-stage CKD. We identified two subnetworks 'triacylglycerols' and 'cardiolipins-phosphatidylethanolamines (CL-PE)' ch

SUBMITTER: Ma J 

PROVIDER: S-EPMC6748777 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature