Recovery of central memory and naive peripheral T cells in Follicular Lymphoma patients receiving rituximab-chemotherapy based regimen.

ABSTRACT: Preclinical models and clinical studies have shown that anti-CD20-based treatment has multifaceted consequences on T-cell immunity. We have performed a prospective study of peripheral T-cell compartment in FL patients, all exhibiting high tumor burden and receiving rituximab-chemotherapy-based regimen (R-CHOP). Before treatment, FL patients harbor low amounts of peripheral naive T cells, but high levels of CD4⁺ T_EM, CD4⁺ T_reg and CD8⁺ T_EMRA subsets and significant amounts of CD38⁺ HLA-DR⁺ activated T cells. A portion of these activated/differentiated T cells also expressed PD-1 and/or TIGIT immune checkpoints. Hierarchical clustering of phenotyping data revealed that 5/8 patients with only a partial res

SUBMITTER: Milcent B 

PROVIDER: S-EPMC6748924 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature