Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery.

ABSTRACT: Hollow titanium dioxide (TiO₂) nanotubes offer substantially higher drug loading capacity and slower drug release kinetics compared to solid drug nanocarriers of comparable size. In this report, we load TiO₂ nanotubes with iron oxide nanoparticles to facilitate site-specific magnetic guidance and drug delivery. We generate magnetic TiO₂ nanotubes (TiO₂NTs) by incorporating a ferrofluid containing Ø ≈ 10 nm iron oxide nanoparticles in planar sheets of weakly connected TiO₂ nanotubes. After thermal annealing, the magnetic tubular arrays are loaded with therapeutic drugs and then sonicated to separate the nanotubes. We demonstrate that magnetic TiO₂NTs are non-toxic for HeLa cells at therapeutic concentrations (≤200 µg/mL). Adh

SUBMITTER: Hasanzadeh Kafshgari M 

PROVIDER: S-EPMC6748954 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature