Identification and characterization of SEC24D as a susceptibility gene for hepatitis B virus infection.

ABSTRACT: Single nucleotide polymorphisms (SNPs) and genes associated with susceptibility to hepatitis B virus (HBV) infection that have been identified by genome-wide association studies explain only a limited portion of the known heritability, indicating more genetic variants remain to be discovered. In this study, we adopted a new research strategy to identify more susceptibility genes and variants for HBV infection. We first performed genetic association analysis of 300 sib-pairs and 3,087 case-control samples, which revealed that 36 SNPs located in 31 genes showed nominal associations with HBV infection in both samples. Of these genes, we selected SEC24D for further molecular analysis according to the following two main lines of evidence. First, a time course analysis of the expression profiles

SUBMITTER: Jiang X 

PROVIDER: S-EPMC6748997 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature