Bacteria Associated With Shiraia Fruiting Bodies Influence Fungal Production of Hypocrellin A.

ABSTRACT: Hypocrellin A (HA) is a natural red perylenequinone pigment from Shiraia fruiting body, which was used clinically on various skin diseases and developed as a photodynamic therapy agent against cancers. The fruiting bodies may harbor a diverse but poorly understood microbial community. In this study, we characterized the bacterial community of Shiraia fruiting body using a combination of culture-based method and Illumina high-throughput sequencing, and tested the involvement of some companion bacteria in fungal HA production using the fungal-bacterial confrontation assay. Our results revealed that the bacterial community in the fruiting body was dominated by Bacillus and Pseudomonas. Some Pseudomonas isolates such as P. fulva, P. putida, and

SUBMITTER: Ma YJ 

PROVIDER: S-EPMC6749022 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature