Mst1-Deficiency Induces Hyperactivation of Monocyte-Derived Dendritic Cells via Akt1/c-myc Pathway.

ABSTRACT: Mst1 is a multifunctional serine/threonine kinase that is highly expressed in several immune organs. The role of Mst1 in the activation of dendritic cells (DCs), a key player of adaptive immunity, is poorly understood. In this study, we investigated the role of Mst1 in GM-CSF-induced bone marrow-derived DCs and the underlying mechanisms. Mst1 ^-/- DCs in response to GM-CSF expressed higher levels of activation/maturation-related cell surface molecules, such as B7 and MHC class II than Mst1 ^+/+ DCs. Furthermore, the expression of proinflammatory cytokines, such as IL-23, TNF-α, and IL-12p40, was increased in Mst1 ^-/- DCs, indicating that Mst1-deficiency may induce the hyperactivation of DCs. Additionally, Mst1 ^-/- DCs ex

SUBMITTER: Cho KM 

PROVIDER: S-EPMC6749027 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature