Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis.

ABSTRACT: In normal conditions gut homeostasis is maintained by the suppressive activity of regulatory T cells (Tregs), characterized by the expression of the transcription factor FoxP3. In human inflammatory bowel disease, which is believed to be the consequence of the loss of tolerance toward antigens normally contained in the gut lumen, Tregs have been found to be increased and functionally active, thus pointing against their possible role in the pathogenesis of this immune-mediated disease. Though, in inflammatory conditions, Tregs have been shown to upregulate the T helper (Th) type 1-related transcription factor Tbet and to express the pro-inflammatory cytokine IFNγ, thus suggesting that at a certain point of the inflammatory process, Tregs might contribute to inflammation rather than suppress

SUBMITTER: Di Giovangiulio M 

PROVIDER: S-EPMC6749075 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature