Molecular Design, Synthesis, and Biological Evaluation of 2-Hydroxy-3-Chrysino Dithiocarbamate Derivatives.

ABSTRACT: A series of 2-hydroxy-3-chrysino dithiocarbamate derivatives (3a-k) were designed, synthesized, and characterized for their structure determination by ¹H NMR, ¹³C NMR, and HRMS (ESI) spectral data. They were screened for their in vitro biological activities against a panel of selected bacterial and fungal strains. These antimicrobial studies indicate that some of the analogues manifested significant activity compared to standard drugs. Among the synthetic analogues (3a-k), compounds 3d, 3f, and 3j exhibited very good antibacterial activity and compounds 3d, 3f, and 3h showed very good antifungal activity compared to the standard drugs penicillin and itrazole, respectively. The compounds 3e, <

SUBMITTER: Ramesh P 

PROVIDER: S-EPMC6749404 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature