Distinct impact of antibiotics on the gut microbiome and resistome: a longitudinal multicenter cohort study.

ABSTRACT:

Background

The selection pressure exercised by antibiotic drugs is an important consideration for the wise stewardship of antimicrobial treatment programs. Treatment decisions are currently based on crude assumptions, and there is an urgent need to develop a more quantitative knowledge base that can enable predictions of the impact of individual antibiotics on the human gut microbiome and resistome.

Results

Using shotgun metagenomics, we quantified changes in the gut microbiome in two cohorts of hematological patients receiving prophylactic antibiotics; one cohort was treated with ciprofloxacin in a hospital in Tübingen and the other with cotrimoxazole in a hospital in Cologne. Analyzing this rich longitudinal dataset, we found that gut microbiome diversity was reduced in bo

SUBMITTER: Willmann M 

PROVIDER: S-EPMC6749691 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature