Hollow gold nanoshells-incorporated injectable genetically engineered hydrogel for sustained chemo-photothermal therapy of tumor.

ABSTRACT:

Background

Combined therapy has demonstrated to be an effective strategy for cancer therapy. Herein, an injectable hydrogel based on the genetically engineered polypeptide and hollow gold nanoshells (HAuNS) has been developed for chemo-photothermal therapy of HepG2 tumor.

Methods

PC₁₀A/DOX/HAuNS nanogel was prepared with layer-by-layer through the adsorption of DOX and PC₁₀A successively. DOX with positive charge and PC₁₀A with negative charge were coated step by step onto the surface of negatively charged HAuNS. The multifunctional hydrogel PC₁₀A/DOX/HAuNS were prepared via dissolving hybrid PC₁₀A/DOX/HAuNS nanogel in polypeptide PC₁₀A. Chemotherapy drug DOX in the PC₁₀A/DOX/HAuNS hydrogel was abso

SUBMITTER: Jin R 

PROVIDER: S-EPMC6749695 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature