The case for a universal hepatitis C vaccine to achieve hepatitis C elimination.

ABSTRACT:

Background

The introduction of highly effective direct-acting antiviral (DAA) therapy for hepatitis C has led to calls to eliminate it as a public health threat through treatment-as-prevention. Recent studies suggest it is possible to develop a vaccine to prevent hepatitis C. Using a mathematical model, we examined the potential impact of a hepatitis C vaccine on the feasibility and cost of achieving the global WHO elimination target of an 80% reduction in incidence by 2030 in the era of DAA treatment.

Methods

The model was calibrated to 167 countries and included two population groups (people who inject drugs (PWID) and the general community), features of the care cascade, and the coverage of health systems to deliver services. Projections were made for 2018-2030.

Result

SUBMITTER: Scott N 

PROVIDER: S-EPMC6749704 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature