Emergence of diversity in carbapenemase-producing <i>Escherichia coli</i> ST131, England, January 2014 to June 2016.

ABSTRACT: BackgroundEscherichia coli ST131, a global, high-risk clone, comprises fluoroquinolone resistance (FQ-R) mutations and CTX-M extended-spectrum beta-lactamases associated with the fimH30-encoding clades, C1 and C2. Further carbapenem resistance development in ST131 is a public health concern.AimThis observational study aimed to probe the diversity of carbapenemase-producing E. coli (CP E. coli) ST131 across England.MethodsST131 isolates were identified using whole-genome sequencing (WGS) data generated for all non-duplicate CP E. coli from human samples submitted to the national reference laboratory from January 2014 to June 2016. Antimicrobial resistance (AMR) gene content and single nucleotide polymorphism (SNP) data were compared against a published ST1

SUBMITTER: Ellaby N 

PROVIDER: S-EPMC6749775 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature