Associations of P2RX7 Functional Diplotypes with Localized Aggressive Periodontitis.

ABSTRACT:

Aim

The purpose of this study was to test for the role of the P2X7 receptor in localized aggressive periodontitis (LAP).

Methods

Peripheral blood was obtained from 95 subjects with LAP and 76 healthy unrelated controls (HUCs). Three P2RX7 single-nucleotide polymorphisms (rs1718119, rs2230911, and rs3751143) were genotyped from these subjects, and their peripheral blood samples were stimulated with lipopolysaccharide (LPS) from Escherichia coli and tested for inflammatory markers. The 3 P2RX7 single-nucleotide polymorphisms were in found to be in perfect linkage disequilibrium, and a total of 4 haplotypes and 9 diplotypes were identified among all subjects. For both subject populations, the 9 diplotypes were grouped into 4 functional groups and tested for association with sub

SUBMITTER: Harris TH 

PROVIDER: S-EPMC6749795 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature