Exercise Interventions in Huntington's Disease: An Individual Patient Data Meta-Analysis.

ABSTRACT:

Background

Physical activity may be beneficial in Huntington's disease (HD); however, studies to date have been underpowered to detect change. We combined data from five randomized controlled feasibility trials using individual patient data meta-analyses.

Methods/design

All trial interventions comprised a combination of supervised and self-directed physical activity, with varied emphasis on aerobic, strength, endurance, flexibility, and task training. Duration ranged from 8 to 16 weeks. The primary outcome was the modified Unified Huntington's Disease Rating Motor Score. Secondary outcomes included the Symbol Digit Modality Test, Berg Balance Scale, 30-second Chair stand, Timed Up and Go, Gait Speed, Physical Performance Test, Six-Minute Walk, International Physical Activity

SUBMITTER: Playle R 

PROVIDER: S-EPMC6749801 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature