Unraveling the effects of peroxiredoxin 2 nitration; role of C-terminal tyrosine 193.

ABSTRACT: Peroxiredoxins (Prx) are enzymes that efficiently reduce hydroperoxides through active participation of cysteine residues (C_P, C_R). The first step in catalysis, the reduction of peroxide substrate, is fast, 10⁷ - 10⁸ M^-1s^-1 for human Prx2. In addition, the high intracellular concentration of Prx positions them not only as good antioxidants but also as central players in redox signaling pathways. These biological functions can be affected by post-translational modifications that could alter the peroxidase activity and/or interaction with other proteins. In particular, inactivation by hyperoxidation of C_P, which occurs when a second molecule of peroxide reacts with the C_P in the sulfenic acid form, modula

SUBMITTER: Randall LM 

PROVIDER: S-EPMC6749834 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature