Highly Porous Microcarriers for Minimally Invasive In Situ Skeletal Muscle Cell Delivery.

ABSTRACT: Microscale cell carriers have recently garnered enormous interest in repairing tissue defects by avoiding substantial open surgeries using implants for tissue regeneration. In this study, the highly open porous microspheres (HOPMs) are fabricated using a microfluidic technique for harboring proliferating skeletal myoblasts and evaluating their feasibility toward cell delivery application in situ. These biocompatible HOPMs with particle sizes of 280-370 µm possess open pores of 10-80 µm and interconnected paths. Such structure of the HOPMs conveniently provide a favorable microenvironment, where the cells are closely arranged in elongated shapes with the deposited extracellular matrix, facilitating cell adhesion and proliferation, as well as augmented myogenic differentiation. Furthermore,

SUBMITTER: Kankala RK 

PROVIDER: S-EPMC6750270 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature