Genetic Risk of Arrhythmic Phenotypes in Patients With Dilated Cardiomyopathy.

ABSTRACT:

Background

Genotype-phenotype correlations in dilated cardiomyopathy (DCM) and, in particular, the effects of gene variants on clinical outcomes remain poorly understood.

Objectives

The purpose of this study was to investigate the prognostic role of genetic variant carrier status in a large cohort of DCM patients.

Methods

A total of 487 DCM patients were analyzed by next-generation sequencing and categorized the disease genes into functional gene groups. The following composite outcome measures were assessed: 1) all-cause mortality; 2) heart failure-related death, heart transplantation, or destination left ventricular assist device implantation (DHF/HTx/VAD); and 3) sudden cardiac death/sustained ventricular tachycardia/ventricular fibrillation (SCD/VT/VF).

Results

SUBMITTER: Gigli M 

PROVIDER: S-EPMC6750731 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature