Dopamine D_2L Receptor Deficiency Causes Stress Vulnerability through 5-HT_1A Receptor Dysfunction in Serotonergic Neurons.

ABSTRACT: Mental disorders are caused by genetic and environmental factors. We here show that deficiency of an isoform of dopamine D₂ receptor (D₂R), D_2LR, causes stress vulnerability in mouse. This occurs through dysfunction of serotonin [5-hydroxytryptamine (5-HT)] 1A receptor (5-HT_1AR) on serotonergic neurons in the mouse brain. Exposure to forced swim stress significantly increased anxiety- and depressive-like behaviors in D_2LR knock-out (KO) male mice compared with wild-type mice. Treatment with 8-OH-DPAT, a 5-HT_1AR agonist, failed to alleviate the stress-induced behaviors in D_2LR-KO mice. In forced swim-stressed D_2LR-KO mice, 5-HT efflux in the medial prefrontal cortex was elevated and the expression of gen

SUBMITTER: Shioda N 

PROVIDER: S-EPMC6750932 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature