Examining raphe-amygdala structural connectivity as a biological predictor of SSRI response.

ABSTRACT:

Background

Our lab has previously found that structural integrity in tracts from the raphe nucleus (RN) to the amygdala, measured by fractional anisotropy (FA), predicts remission to selective serotonin reuptake inhibitors (SSRIs) in major depressive disorder (MDD). This could potentially serve as a biomarker for remission that can guide clinical decision-making. To enhance repeatability and reproducibility, we replicated our study in a larger, more representative multi-site sample.

Methods

64 direction DTI was collected in 144 medication-free patients with MDD from the Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC) study. We performed probabilistic tractography between the RN and bilateral amygdala and hippocampus and calcula

SUBMITTER: Pillai RLI 

PROVIDER: S-EPMC6750958 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature