Repeatability of regional pulmonary functional metrics of Hyperpolarized ¹²⁹ Xe dissolved-phase MRI.

ABSTRACT:

Background

MRI of hyperpolarized ¹²⁹ Xenon (HP ¹²⁹ Xe) is increasingly utilized for investigating pulmonary function. The solubility of HP ¹²⁹ Xe in lung tissue, blood plasma (Barrier), and red blood cells (RBC), with unique chemical shifts, enables spectroscopic imaging of potential imaging biomarkers of gas exchange and microstructural pulmonary physiology.

Purpose

To quantify global average and regional repeatability of Barrier:gas, RBC:gas, and RBC:Barrier ratios derived from dissolved-phase ¹²⁹ Xe imaging and their dependence on intervisit changes in lung inflation volume.

Study type

Prospective.

Population

Fourteen healthy volunteers. One subject was unable to complete the study resulting in 13 subjects for anal

SUBMITTER: Hahn AD 

PROVIDER: S-EPMC6750965 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature