Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signaling.

ABSTRACT: The maintenance of proteostasis is crucial for any organism to survive and reproduce in an ever-changing environment, but its efficiency declines with age¹. Posttranscriptional regulators such as microRNAs control protein translation of target mRNAs with major consequences for development, physiology, and longevity^2,3. Here we show that food odor stimulates organismal proteostasis and promotes longevity in Caenorhabditis elegans through mir-71-mediated inhibition of tir-1 mRNA stability in olfactory AWC neurons. Screening a collection of microRNAs that control aging³ we find that miRNA mir-71 regulates lifespan and promotes ubiquitin-dependent protein turnover, particularly in the intestine. We show that mir-71 directly in

SUBMITTER: Finger F 

PROVIDER: S-EPMC6751085 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature