Pilot Study of Metabolomic Clusters as State Markers of Major Depression and Outcomes to CBT Treatment.

ABSTRACT: Major depressive disorder (MDD) is a common and disabling syndrome with multiple etiologies that is defined by clinically elicited signs and symptoms. In hopes of developing a list of candidate biological measures that reflect and relate closely to the severity of depressive symptoms, so-called "state-dependent" biomarkers of depression, this pilot study explored the biochemical underpinnings of treatment response to cognitive behavior therapy (CBT) in medication-free MDD outpatients. Plasma samples were collected at baseline and week 12 from a subset of MDD patients (N = 26) who completed a course of CBT treatment as part of the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) study. Targeted metabolomic profiling using the AbsoluteIDQ® p180 Kit and LC

SUBMITTER: Bhattacharyya S 

PROVIDER: S-EPMC6751322 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature