Combination of Trastuzumab Emtansine and Stereotactic Radiosurgery Results in High Rates of Clinically Significant Radionecrosis and Dysregulation of Aquaporin-4.

ABSTRACT:

Purpose

Patients with human EGFR2-positive (HER2⁺) breast cancer have a high incidence of brain metastases, and trastuzumab emtansine (T-DM1) is often employed. Stereotactic radiosurgery (SRS) is frequently utilized, and case series report increased toxicity with combination SRS and T-DM1. We provide an update of our experience of T-DM1 and SRS evaluating risk of clinically significant radionecrosis (CSRN) and propose a mechanism for this toxicity.

Experimental design

Patients with breast cancer who were ≤45 years regardless of HER2 status or had HER2⁺ disease regardless of age and underwent SRS for brain metastases were included. Rates of CSRN, SRS data, and details of T-DM1 administration were recorded. Proliferation and astrocytic swelling studies we

SUBMITTER: Stumpf PK 

PROVIDER: S-EPMC6751332 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature