Exploring the complex associations over time among albendazole treatment, cyst evolution, and seizure outcomes in neurocysticercosis.

ABSTRACT:

Objective

To develop a causal model for the occurrence of neurocysticercosis (NC)-related seizures and test hypotheses generated from the model.

Methods

We used data from a randomized controlled trial comparing albendazole with placebo among patients newly diagnosed with NC. Based on our causal model, we explored the associations among albendazole treatment, NC cyst evolution, and seizure outcomes over 24 months of follow-up using generalized linear mixed effect models.

Results

We included 153 participants, of whom 51% received albendazole. The association between seizure outcomes and treatment over time demonstrated lack of linearity and heterogeneity, requiring the inclusion of time-treatment interaction terms for valid modeling. Participants in the albendazole grou

SUBMITTER: Carpio A 

PROVIDER: S-EPMC6751555 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature