Phase II clinical trial of pembrolizumab efficacy and safety in advanced adrenocortical carcinoma.

ABSTRACT:

Background

Adrenocortical carcinoma (ACC) is a rare malignancy without good treatment options. There are limited data about the use of immunotherapy in ACC. We investigated the efficacy and safety of pembrolizumab in patients with metastatic ACC.

Methods

This is a pre-specified cohort of a single-center, investigator-initiated, phase II clinical trial using pembrolizumab monotherapy in patients with rare malignancies. Patients must have had prior treatment fail in the past 6 months before study enrollment. Patients were enrolled from August 2016 to October 2018. Follow-up data were updated as of March 26, 2019. Patients received 200 mg pembrolizumab intravenously every 3 weeks without concomitant oncologic therapy. The primary endpoint was non-progression rate (NPR) at 27 we

SUBMITTER: Habra MA 

PROVIDER: S-EPMC6751592 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature