Ontology highlight
ABSTRACT:
SUBMITTER: Zhu X
PROVIDER: S-EPMC6751633 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Zhu Xinxing X Chen Duchu D Liu Yanli Y Yu Jinjin J Qiao Liang L Lin Shuibin S Chen Demeng D Zhong Genshen G Lu Xifeng X Wang Yize Y Wen Jieqi J Zhong Xinqi X Jiang Yizhou Y
Molecular and cellular biology 20190911 19
The long noncoding RNA HOXA-AS3 has recently been reported to act as a critical regulator in inflammation-linked lung adenocarcinoma. However, the roles of HOXA-AS3 in endothelium inflammation and related vascular disorders remain poorly defined. In the current study, we identified HOXA-AS3 to be a critical activator to promote NF-κB-mediated endothelium inflammation. HOXA-AS3, a chromatin-associated regulator which colocalizes with NF-κB at specific gene promoters, was found to interact with NF ...[more]