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Long Noncoding RNA HOXA-AS3 Integrates NF-?B Signaling To Regulate Endothelium Inflammation.


ABSTRACT: The long noncoding RNA HOXA-AS3 has recently been reported to act as a critical regulator in inflammation-linked lung adenocarcinoma. However, the roles of HOXA-AS3 in endothelium inflammation and related vascular disorders remain poorly defined. In the current study, we identified HOXA-AS3 to be a critical activator to promote NF-?B-mediated endothelium inflammation. HOXA-AS3, a chromatin-associated regulator which colocalizes with NF-?B at specific gene promoters, was found to interact with NF-?B and positively regulate its activity through control of the expression of the NF-?B inhibitor protein I?B? and the acetylation status at the K310 site of p65. More importantly, clinicopathological analysis showed that HOXA-AS3 expression has a significant positive correlation with atherosclerosis. Thus, we conclude that HOXA-AS3 may serve as a crucial biomarker for the clinical diagnosis of atherosclerosis, as well as a promising therapeutic target for the treatment of multiple inflammatory vascular diseases. In addition, this study suggests the functional importance of HOXA-AS3 in the regulation of inflammatory disorders.

SUBMITTER: Zhu X 

PROVIDER: S-EPMC6751633 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Long Noncoding RNA HOXA-AS3 Integrates NF-κB Signaling To Regulate Endothelium Inflammation.

Zhu Xinxing X   Chen Duchu D   Liu Yanli Y   Yu Jinjin J   Qiao Liang L   Lin Shuibin S   Chen Demeng D   Zhong Genshen G   Lu Xifeng X   Wang Yize Y   Wen Jieqi J   Zhong Xinqi X   Jiang Yizhou Y  

Molecular and cellular biology 20190911 19


The long noncoding RNA HOXA-AS3 has recently been reported to act as a critical regulator in inflammation-linked lung adenocarcinoma. However, the roles of HOXA-AS3 in endothelium inflammation and related vascular disorders remain poorly defined. In the current study, we identified HOXA-AS3 to be a critical activator to promote NF-κB-mediated endothelium inflammation. HOXA-AS3, a chromatin-associated regulator which colocalizes with NF-κB at specific gene promoters, was found to interact with NF  ...[more]

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