Photopheresis efficacy in the treatment of rheumatoid arthritis: a pre-clinical proof of concept.

ABSTRACT:

Background

Despite major advances in rheumatoid arthritis outcome, not all patients achieve remission, and there is still an unmet need for new therapeutic approaches. This study aimed at evaluating in a pre-clinical murine model the efficacy of extracorporeal photopheresis (ECP) in the treatment of rheumatoid arthritis, and to provide a relevant study model for dissecting ECP mechanism of action in autoimmune diseases.

Methods

DBA/1 mice were immunized by subcutaneous injection of bovine collagen type II, in order to initiate the development of collagen-induced arthritis (CIA). Arthritic mice received 3 ECP treatments every other day, with psoralen + UVA-treated (PUVA) spleen cells obtained from arthritic mice. Arthritis score was measured, and immune cell subsets were moni

SUBMITTER: Coppard C 

PROVIDER: S-EPMC6751641 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature