Genome-Wide DNA Methylation Model for the Diagnosis of Prostate Cancer.

ABSTRACT: Prostate cancer is the most prevalent and the second most lethal malignancy among males in the United States of America. Its diagnosis is almost entirely predicated upon histopathological analysis of the biopsied tissue, and it is associated with a substantial average error. Using genome-wide DNA methylation data derived from 469 prostatic tumor tissue samples and 50 normal prostatic tissue samples and interrogating over 485 000 CpG sites per sample (spanning across gene promoters, CpG islands, shores, shelves, gene bodies, and intergenic and other areas), we were able to develop a mathematical model that classified with a high accuracy (overall sensitivity = 95.31% and overall specificity = 94.00%) tumor tissue versus normal tissue. The methylation β values of five CpG sites, correspondin

SUBMITTER: Nikas JB 

PROVIDER: S-EPMC6751714 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature