In Vivo Imaging of Translocator Protein in Long-term Cannabis Users.

ABSTRACT:

Importance

Cannabis is the most commonly used illicit drug in the world. Cannabinoids have been shown to modulate immune responses; however, the association of cannabis with neuroimmune function has never been investigated in vivo in the human brain.

Objective

To investigate neuroimmune activation or 18-kDa translocator protein (TSPO) levels in long-term cannabis users, and to evaluate the association of brain TSPO levels with behavioral measures and inflammatory blood biomarkers.

Design, setting, and participants

This cross-sectional study based in Toronto, Ontario, recruited individuals from January 1, 2015, to October 30, 2018. Participants included long-term cannabis users (n = 24) and non-cannabis-using controls (n = 27). Cannabis users were included if they had

SUBMITTER: Da Silva T 

PROVIDER: S-EPMC6751758 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature