SLC39A8 is a risk factor for schizophrenia in Uygur Chinese: a case-control study.

ABSTRACT:

Background

Schizophrenia is a severe mental disease with high morbidity and heritability. The SLC39A8 gene is located in 4q24 and encodes a protein that transports many metal ions. Multiple previous studies found that one of the most pleiotropic single nucleotide polymorphisms (SNPs) in SLC39A8, rs13107325, is associated with schizophrenia in the European population. However, the polymorphism of this locus is rare in other populations. In China, the Han Chinese and the Uygur Chinese are two ethnic populations that originate from different races.

Methods

A case-control study was conducted with 983 schizophrenia cases and 1230 healthy controls of the Chinese Uygur population. To validate the most promising SNP, meta-analyses were conducted with the Han Chinese and the European

SUBMITTER: Jian X 

PROVIDER: S-EPMC6751796 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature