Association of Cytomegalovirus and Toxoplasma gondii Antibody Titers With Bipolar Disorder.

ABSTRACT:

Importance

Infection-associated immune activation and inflammation are increasingly recognized in the pathophysiology of bipolar disorder.

Objective

To determine whether antibodies to common infectious agents, including cytomegalovirus (CMV), Toxoplasma gondii, and measles, as well as the inflammatory marker C-reactive protein, in serum samples differ between patients with bipolar disorder and control individuals without bipolar disorder.

Design, setting, and participants

In this case-control study, antibody titers were measured in serum samples from 1207 patients with bipolar disorder and 745 controls that were obtained from biobanks with participating sites in Rochester and Minneapolis, Minnesota (n = 1537), and Cincinnati, Ohio (n = 415), from January 5, 2009, thro

SUBMITTER: Frye MA 

PROVIDER: S-EPMC6751798 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature