Defective angiogenesis in CXCL12 mutant mice impairs skeletal muscle regeneration.

ABSTRACT:

Background

During muscle regeneration, the chemokine CXCL12 (SDF-1) and the synthesis of some specific heparan sulfates (HS) have been shown to be critical. CXCL12 activity has been shown to be heavily influenced by its binding to extracellular glycosaminoglycans (GAG) by modulating its presentation to its receptors and by generating haptotactic gradients. Although CXCL12 has been implicated in several phases of tissue repair, the influence of GAG binding under HS influencing conditions such as acute tissue destruction remains understudied.

Methods

To investigate the role of the CXCL12/HS proteoglycan interactions in the pathophysiology of muscle regeneration, we performed two models of muscle injuries (notexin and freeze injury) in mutant CXCL12^Gagtm/Gagtm mice,

SUBMITTER: Hardy D 

PROVIDER: S-EPMC6751827 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature