Chronic toxicity of low dose monosodium glutamate in albino Wistar rats.

ABSTRACT:

Objective

The objective of this study was to observe the effects of chronic dosing with monosodium glutamate on mortality, fertility, major organ functions and histology in albino Wistar rats.

Results

6 male and 6 female rats (age 6 weeks) were bred in a cage, feeding on standard growers' mash, with monosodium glutamate added (120 mg/kg/day). 12 corresponding breeding rats (on standard feed without MSG) were controls. Chronic dosing with monosodium glutamate in albino Wistar rats (at a dose consistent with the human ADI) led to increased mortality, fertility impairment, and significant changes in major organ function tests and histology. 23 deaths were recorded in the rats fed with MSG additive, while mortality was zero in the control animals. Fertility was lower in rats on

SUBMITTER: Nnadozie JO 

PROVIDER: S-EPMC6751858 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature