Alternative methods improve the accuracy of genomic prediction using information from a causal point mutation in a dairy sheep model.

ABSTRACT:

Background

Genomic evaluation is usually based on a set of markers assumed to be linked with causal mutations. Selection and precise management of major genes and the remaining polygenic component might be improved by including causal polymorphisms in the evaluation models. In this study, various methods involving a known mutation were used to estimate prediction accuracy. The SOCS2 gene, which influences body growth, milk production and somatic cell scores, a proxy for mastitis, was studied as an example in dairy sheep.

Methods

The data comprised 1,503,148 phenotypes and 9844 54K SNPs genotypes. The SOCS2 SNP was genotyped for 4297 animals and imputed in the above 9844 animals. Breeding values and their accuracies were estimated for each of nine traits by using single-step

SUBMITTER: Oget C 

PROVIDER: S-EPMC6751880 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature