Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors.

ABSTRACT:

Background

Programmed cell death 1 inhibitors have revolutionized therapy for cancer by their outstanding effectiveness. However, they may cause adverse effects, among which inflammatory myopathy is one of the most disabling. To elucidate its mechanism, we analysed muscle biopsies and compared them with other inflammatory myopathies.

Methods

Muscle biopsies from three patients with inflammatory myopathy after treatment with PD-1 inhibitors for cancer were subjected to immunohistochemical and ultrastructural analyses to localize CD8+ cytotoxic cells and markers of lymphoid follicles. For comparison, two cases of polymyositis and one of juvenile dermatomyositis were examined.

Results

Nearly identical pathological features were observed in the three cases. In the island-

SUBMITTER: Matsubara S 

PROVIDER: S-EPMC6751882 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature