Circular RNA expression profile in the spinal cord of morphine tolerated rats and screen of putative key circRNAs.

ABSTRACT: Morphine tolerance developed after repeated or continuous morphine treatment is a global health concern hindering the control of chronic pain. In our previous research, we have reported that the expression of lncRNAs and microRNAs have been greatly modified in the spinal cord of morphine tolerated rats, and the modulating role of miR-873a-5p, miR-219-5p and miR-365 have already been confirmed. However, whether circular RNAs, another essential kind of non-coding RNA, are involved in the pathogenesis of morphine tolerance is still beyond our knowledge. In this study, we conducted microarray analysis for circRNA profile and found a large number of circRNAs changed greatly in the spinal cord by morphine treatment. Among them, we selected nine circRNAs for validation, and seven circRNAs are con

SUBMITTER: Weng Y 

PROVIDER: S-EPMC6751888 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature