Identification of novel cerebellar developmental transcriptional regulators with motif activity analysis.

ABSTRACT:

Background

The work of the FANTOM5 Consortium has brought forth a new level of understanding of the regulation of gene transcription and the cellular processes involved in creating diversity of cell types. In this study, we extended the analysis of the FANTOM5 Cap Analysis of Gene Expression (CAGE) transcriptome data to focus on understanding the genetic regulators involved in mouse cerebellar development.

Results

We used the HeliScopeCAGE library sequencing on cerebellar samples over 8 embryonic and 4 early postnatal times. This study showcases temporal expression pattern changes during cerebellar development. Through a bioinformatics analysis that focused on transcription factors, their promoters and binding sites, we identified genes that appear as strong candidates for i

SUBMITTER: Ha TJ 

PROVIDER: S-EPMC6751898 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature