AURKB: a promising biomarker in clear cell renal cell carcinoma.

ABSTRACT:

Background

Aurora kinase B (AURKB) is an important carcinogenic factor in various tumors, while its role in clear cell renal cell carcinoma (ccRCC) still remains unclear. This study aimed to investigate its prognostic value and mechanism of action in ccRCC.

Methods

Gene expression profiles and clinical data of ccRCC patients were downloaded from The Cancer Genome Atlas database. R software was utilized to analyze the expression and prognostic role of AURKB in ccRCC. Gene set enrichment analysis (GSEA) was used to analyze AURKB related signaling pathways in ccRCC.

Results

AURKB was expressed at higher levels in ccRCC tissues than normal kidney tissues. Increased AURKB expression in ccRCC correlated with high histological grade, pathol

SUBMITTER: Wan B 

PROVIDER: S-EPMC6752188 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature