Interlaboratory Analysis of Isavuconazole Plasma Concentration Assays Among European Laboratories.

ABSTRACT: BACKGROUND:Under certain circumstances, clinicians treating patients with isavuconazole for invasive aspergillosis or mucormycosis may use therapeutic drug monitoring. However, the accuracy and reproducibility of the various assays used by different laboratories for the quantification of isavuconazole plasma concentrations have yet to be determined. METHODS:Human plasma samples spiked with known concentrations of isavuconazole were provided to 27 European laboratories that took part in a "round-robin" test (an interlaboratory test performed independently at least 2 times; 2 rounds performed in the current study). Assay methods included liquid chromatography-tandem mass spectrometry (LC-MS/MS), LC with ultraviolet detection (LC-UV), LC with fluorescence detection (LC-FL), and bioassay. The

SUBMITTER: Pea F 

PROVIDER: S-EPMC6752689 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature