Ontology highlight
ABSTRACT:
SUBMITTER: Garske KM
PROVIDER: S-EPMC6752726 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Garske Kristina M KM Pan David Z DZ Miao Zong Z Bhagat Yash V YV Comenho Caroline C Robles Christopher R CR Benhammou Jihane N JN Alvarez Marcus M Ko Arthur A Ye Chun Jimmie CJ Pisegna Joseph R JR Mohlke Karen L KL Sinsheimer Janet S JS Laakso Markku M Pajukanta Päivi P
Nature metabolism 20190614 6
Identifying gene-environment interactions (GxEs) contributing to human cardiometabolic disorders is challenging. Here we apply a reverse GxE candidate search by deriving candidate variants from promoter-enhancer interactions that respond to dietary fatty acid challenge through altered chromatin accessibility in human primary adipocytes. We then test all variants residing in the lipid-responsive open chromatin sites within adipocyte promoter-enhancer contacts for interaction effects between the g ...[more]